ExAnte Labs
Optifold
Experimental 7SQG chain A backbone

Optifold.

A sequence-based research score for prioritizing protein-folding experiments.

Open workspace Research notes

Calculate the Optifold score

350 residuesDownload example

Optifold score

—

S=0.67 z(H)+0.33 z(−D)S = 0.67\,z(H) + 0.33\,z(-D)
—Mean hydropathy (H)
—Disorder-promoting fraction (D)
How the scaling works
See the calculation
Scaled hydropathy—
Scaled −D—

H is mean Kyte–Doolittle hydropathy. D counts A, R, G, Q, S, P, E and K, divided by sequence length. It measures composition rather than locating disordered regions.

Contributing residues: —

Original primary rule

The study retains D ≤ 0.5641 as its preregistered primary analysis. The combined score above is the named secondary model.

Ready when you are.

Calculate to compare with the original rule.

0Original threshold 0.56411